A 3-Year Evaluation Study on Fine Needle Aspiration Cytology and Corresponding Histology
Background and Objectives: Incidence of thyroid carcinoma has been increasing world-wide. In the present study, we evaluated diagnostic accuracy of Fine needle aspiration (FNA) and its efficiency in early detecting neoplastic lesions of thyroid gland over a 3-year period. Methods: Data have been retrieved from pathology files in King Khalid Hospital. For each patient, age, gender, FNA, site & size of nodule and final histopathologic diagnosis were recorded. Results: Study included 490 cases where 419 of them were female and 71 male. Male to female ratio was 1:6. Mean age was 43 years for males and 38 for females. Cases with confirmed histopathology were 131. In 101/131 (77.1%), concordance was found between FNA and histology. In 30/131 (22.9%), there was discrepancy in diagnosis. Total malignant cases were 43, out of which 14 (32.5%) were true positive and 29 (67.44%) were false negative. No false positive cases could be found in our series. Conclusion: FNA could diagnose benign nodules in all cases, however, in malignant cases, ultrasound findings have to be taken into consideration to avoid missing of a microcarcinoma in the contralateral lobe.
 Seada LS, Al Rashid F, Negm A: A four-year Study of Thyroid Carcinoma in Hail Region: Increased Incidence. International Journal for Medical, Health, Biochemical, Bioengineering and Pharmaceutical Engineering. Vol:10, No:12, 2016.
 Khoo ML, Asa SL, Witterick IJ, Freeman JL: Thyroid calcification and its association with thyroid carcinoma. Head Neck. Jul;24(7):651-5. 2002.
 Mundasad B, Mcallister I, Carson J, Pyper P. Accuracy of fine needle aspiration cytology in diagnosis of thyroid swellings. Internet J Endocrinol 2006.
 H. Galera-Davidson: Diagnostic problems in thyroid fine needle aspirations. Diagn Cytopathol, 17 (1997), pp. 422–428.
 Z.W. Baloch, M.J. Sack, G.H. Yu, V.A. Livolsi, P.K. Gupta: Fine needle aspiration of thyroid an institutional experience. Thyroid, 8 (1998), pp. 565–569.
 Lee MJ, Kim EK, Kwak JY, Kim MJ. Partially cystic thyroid nodules on ultrasound: probability of malignancy and sonographic differentiation. Thyroid 2009; 19:341–346.
 Lin JD, Hsuen C, Chen JY, Liou MJ, Chao TC. Cystic change in thyroid cancer. ANZ J Surg 2007; 77:450–454.
 Choi KU, Kim JY, Park DY, et al. Recommendations for the management of cystic thyroid nodules. ANZ J Surg 2005; 75:537–541.
 Bommanahalli B, Bhat R, and R Rupanarayan: A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study. J Cytol. 2010 Oct; 27(4): 127–132.
 I. V. Renuka, G. Saila Bala, C. Aparna, Ramana Kumari, and K. Sumalatha: The Bethesda System for Reporting Thyroid Cytopathology: Interpretation and Guidelines in Surgical Treatment. Indian J Otolaryngol Head Neck Surg. 2012 Dec; 64(4): 305–311.
 Basharat R, Bukhari MH, Saeed S, Hamid T: Comparison of Fine Needle Aspiration Cytology and Thyroid Scan in Solitary Thyroid Nodule Pathology Research International Volume 2011 Article ID 754041, 9 pages.2011
 Meko JB, Norton JA: Large cystic/solid thyroid nodules: a potential false-negative fine-needle aspiration. Surgery. 1995 Dec;118(6):996-1003
 Manon Auger: Hürthle cells in fine-needle aspirates of the thyroid: A review of their diagnostic criteria and significance. Cancer Cytopathology. Volume 122, Issue 4, pages 241–249, April 2014
 Hürthle K. Beiträge zur Kenntniss des sekretionsvorgangs in der schilddrüse. Arch Gesammte Physiolie Menschen Thiere.1894;56:1-44.
 Mete O, Asa SL. Oncocytes, oxyphils, Hürthle, and Askanazy cells: morphological and molecular features of oncocytic thyroid nodules. Endocr Pathol. 2010;21:16-24.
 Giorgadze T, Rossi ED, Fadda G, Gupta PK, LiVolis VA, Baloch Z. Does the fine-needle aspiration diagnosis of “Hürthle cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol. 2004;31:307-312.
 Agcaoglu O, Aksakal N, Ozcinar B, Sarici IS et al : Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules .International Journal of Endocrinology Volume 2013 , 1-5 (2013).
 Scott N. Pinchot, Hatem Al-Wagih, Sarah Schaefer, Rebecca Sippel,Herbert C: Accuracy of fine-needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules 4 cm or larger . Arch Surg. 2009 July; 144(7): 649–655.2009.
 Michael W. Yeh; Orhan Demircan; Philip Ituarte; Orlo H. Clark: False-Negative Fine-Needle Aspiration Cytology Results Delay Treatment and Adversely Affect Outcome in Patients with Thyroid Carcinoma Thyroid. 2004;14(3)
 Dong Gyu Na, Dae Sik Kim, Soo Jin Kim, Jae Wook Ryoo, So Lyung Jung: Thyroid nodules with isolated macrocalcification: malignancy risk and diagnostic efficacy of fine-needle aspiration and core needle biopsy. Ultrasonography 2016; 35(3): 212-219.