A Study on the Effects of Prolactin and Its Abnormalities on Semen Parameters of Male White Rats
Male factor infertility due to endocrine disturbances
such as abnormalities in prolactin levels are encountered in a
significant proportion. This case control study was carried out to
determine the effects of prolactin on the male reproductive tract,
using 200 male white rats. The rats were maintained as the control
group (G1), hypoprolactinaemic group (G2), 3 hyperprolactinaemic
groups induced using oral largactil (G3), low dose fluphenazine (G4)
and high dose fluphenazine (G5). After 100 days, rats were subjected
to serum prolactin (PRL) level measurements and for basic seminal
fluid analysis (BSA). The difference between serum PRL
concentrations of rats in G2, G3, G4 and G5 as compared to the
control group were highly significant by Student’s t-test (p<0.001).
There were statistically significant differences in seminal fluid
characteristics of rats with induced prolactin abnormalities when
compared with those of control group (p value <0.05), effects were
more marked as the PRL levels rise.
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