Determination of Some Biochemical Parameters in Women during the First Trimester of Pregnancy (Normal Pregnancy and Missed Miscarriage)
Our study was designed to determine the metabolic
changes of some biochemical parameters (cholesterol, triglyceride,
Iron, uric acid, Urea and folic acid) and highlight their changes in 57
women of the region Batna, during the first trimester of pregnancy.
This practical work was done with 27 women with missed
miscarriage, compared with 30 control subjects of normal pregnant
women. The assay results revealed a highly significant difference (P
= 0.0006) between the two groups in serum iron (64.00 vs 93.54) and
in the rate of folate (6.70 vs 9.22) (P <0.001) but no difference was
found regarding the rate of Ca (9.69 vs 10.20), urea (0.19 vs 0.17),
UA (33.96 vs 32.76), CH (1.283 vs 1.431), and TG (0.8852 vs
0.8290). The present study indicates that iron deficiency and folate
are associated with missed miscarriage, but no direct
pathophysiological link has been determined. Further in-depth studies
are needed to determine the exact mechanism by which these deficits
lead to a missed miscarriage.
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