Laser beam micro-drilling (LBMD) is one of the most important non-contact machining processes of materials that are difficult to machine by means oeqf conventional machining methods used in various industries. The paper is focused on LBMD knock-down effect on Ti-6Al-4V (Grade 5) titanium alloy sheets properties. Two various process configurations were verified with a focus on laser damages in back-structure parts affected by the process. The effects of the LBMD on the material properties were assessed by means of tensile and fatigue tests and fracture surface analyses. Fatigue limit of LBMD configurations reached a significantly lower value between 15% and 30% of the static strength as compared to the reference raw material with 58% value. The farther back-structure configuration gives a two-fold fatigue life as compared to the closer LBMD configuration at a given stress applied.
 AFLoNEXT (2nd Generation Active Wing - Active Flow, Loads & Noise control on next generation wing) 7P European project No. 604013, http://www.aflonext.eu/.
 ISO 6892-1:2016, Metallic materials -- Tensile testing -- Part 1: Method of test at room temperature, July 2016.
 EN 6072, Aerospace series - Metallic materials - Test methods - Constant amplitude fatigue testing, 2010.
 M. Kadlec, I. Mlch, R. Růžek, “Fatigue Behaviour of Bolted Joints without Load Transfer,” in EAN 2017 Conference on Experimental Stress Analysis, Slovakia; 2017, pp. 505-508, EID 2-s2.0-85026312595.